PDE1-IN-9 (Compound 7a) hydrochloride is a selective inhibitor for phosphodiesterase 1 (PDE1), that inhibits PDE1C with an IC50 of 11 nM. PDE1-IN-9 hydrochloride reduces mRNA expression of IL-1beta, IL-6, TNF-alpha and iNOS, inhibits the production of nitric oxide (NO) and reactive oxygen species (ROS). PDE1-IN-9 hydrochloride exhibits good metabolic stability in rat liver microsomes[1].
Molecular Weight:
478.03
Purity:
98.74
Formula:
C28H32ClN3O2
Target:
Interleukin Related,NO Synthase,Phosphodiesterase (PDE),Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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