GSK4418959 (IDE275) is a selective, reversible and orally active WRN helicase inhibitor. GSK4418959 shows >10,000-fold selectivity over other helicases. GSK4418959 inhibits ATPase and DNA unwinding functions in an ATP-competitive manner. GSK4418959 can be used for the study of microsatellite instability-high (MSI-H) cancer, such as colorectal cancer (CRC) and endometrial cancer (EC)[1].
Molecular Weight:
646.65
Purity:
99.07
CAS Number:
[3064599-36-3]
Formula:
C31H30F4N4O5S
Target:
DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound
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