NPC26 is a small molecule mitochondrial disruptor with anti-tumor activity. NPC-26 shows significant anti-proliferative and cytotoxic effects on CRC cell lines (HCT-116, DLD-1, and HT-29). NPC26 can damage mitochondrial function, leading to the opening of the mitochondrial permeability transition pore (mPTP) and the production of reactive oxygen species, ultimately inducing cell death. NPC-26 can kill CRC cells by activating the AMP-activated protein kinase (AMPK) signaling pathway[1].
Molecular Weight:
437.53
Purity:
98
CAS Number:
[864860-32-2]
Formula:
C19H23N3O5S2
Target:
AMPK,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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