NA-17 is a naphthalimide compound with anti-tumor activity and lower toxicity to normal cells like HL-7702 and WI-38. NA-17 exhibits a p53-dependent selective inhibition in various NSCLC cells, inducing the accumulation of active p53 in the mitochondria and nuclei of NSCLC cells. NA-17 can cause cell cycle arrest in the G1 phase, leading to apoptosis and cell death[1].
Molecular Weight:
445.51
CAS Number:
[1708948-28-0]
Formula:
C26H27N3O4
Target:
Apoptosis,MDM-2/p53
Application Notes:
Reference compound
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