Dihexa, an oligopeptide drug, is an orally active and blood-brain barrier-permeable angiotensin IV analog. Dihexa binds to hepatocyte growth factor (HGF) with high affinity (Kd=65 pM) and potentiates its activity at its receptor, c-Met. Dihexa exhibits excellent antidementia activity and improves cognitive function in animal models. Dihexa may have therapeutic potential as a treatment Alzheimers disease[1][2].
Molecular Weight:
504.66
Purity:
98.92
CAS Number:
[1401708-83-5]
Formula:
C27H44N4O5
Target:
c-Met/HGFR
Application Notes:
Reference compound
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