VVD 065 is an orally active KEAP1-dependent NRF2 molecular glue degrader with a KEAP1 KD of 65 nM. VVD 065 covalently engages KEAP1 at Cys151, allosterically stabilizes KEAP1-CUL3 complex formation and enhances NRF2 polyubiquitination and proteasomal degradation. VVD 065 can be used for the research of esophageal squamous cell carcinoma, lung cancer, head-and-neck cancer, uterine cancers[1][2][3].
Molecular Weight:
345.78
Purity:
99.71
CAS Number:
[3034876-85-9]
Formula:
C16H16ClN5O2
Target:
Keap1-Nrf2,Molecular Glues
Application Notes:
MCE Product type: Reference compound
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