PKZ18 is an antibiotic and inhibits bacterial growth, with MIC values of 32-64 µg/mL against most Gram-positive bacteria. PKZ18 inhibits in vivo transcription and translation of glycyl-tRNA synthetase mRNA. PKZ18 selectively targets stem I specifier loops in Gram-positive bacteria and directly reduces T-box transcriptional read-through of the associated genes. PKZ18 prevents the codon-anticodon reading required for tRNA binding and is refractory to resistance[1][2].
Molecular Weight:
398.52
CAS Number:
[849658-87-3]
Formula:
C22H26N2O3S
Target:
Antibiotic,Bacterial
Application Notes:
MCE Product type: Oligonucleotides
* VAT and and shipping costs not included. Errors and price changes excepted
