Igmesine hydrochloride (JO 1784) is an orally active sigma-receptor ligand capable of blocking the increase in colonic electromechanical activity induced by emotional stress. Igmesine hydrochloride also eliminates the colonic motility stimulation induced by dopamine, as well as the stimulation induced by centrally injected D1 or D2 receptor agonists. Furthermore, Igmesine hydrochloride can block the colonic motility responses induced by corticotropin-releasing factor (CRF) and ES through central cholecystokinin (CCK) release and/or activation of supraspinal CCK pathways[1][2].
Molecular Weight:
355.94
CAS Number:
[130152-35-1]
Formula:
C23H30ClN
Target:
Sigma Receptor
Application Notes:
MCE Product type: Reference compound
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