HDM-IN-1 (Compound A4) is an inhibitor for fungal histone demethylase (HDM), that inhibits the H3K27me3 in Cryptococcus neoformans and in Candida auris with IC50s of 134 and 12 nM. HDM-IN-1 exhibits inhibitory efficacy against C. neoformans and C. auris with MIC80 of 0.5-2 µg/mL, through inhibition of the biofilm and capsule formation. HDM-IN-1 exhibits antifungal activity in ICR mouse model[1].
Molecular Weight:
305.33
CAS Number:
[3020690-76-7]
Formula:
C17H15N5O
Target:
Fungal,Histone Demethylase
Application Notes:
MCE Product type: Reference compound
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