W-54011 is a potent and orally active non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils with a Ki value of 2.2 nM. W-54011 also inhibits C5a-induced intracellular Ca2+ mobilization, chemotaxis, and generation of ROS in human neutrophils with IC50s of 3.1 nM, 2.7 nM, and 1.6 nM, respectively[1].
Molecular Weight:
493.08
Purity:
99.57
CAS Number:
[405098-33-1]
Formula:
C30H37ClN2O2
Target:
Complement System,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound1
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