OICR-9429, a chemical probe, is high affinity WD repeat domain 5 (WDR5) inhibitor, competitively blocks WDR5 interaction with MLL protein via binding the central peptide-binding pocket of WDR5. OICR-9429 can suppress histone H3K4 trimethylation and can be used for the research of various cancers including non-MLL-rearranged leukaemia, colon, pancreatic, prostate cancer and bladder cancer (BCa) [1].
Molecular Weight:
555.59
Purity:
99.71
CAS Number:
[1801787-56-3]
Formula:
C29H32F3N5O3
Target:
Apoptosis,WDR5
Application Notes:
MCE Product type: Reference compound1
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