TAK-756 is a selective transforming growth factor beta-activated kinase 1 (TAK1) inhibitor with a target pIC50 of 8.6. TAK-756 can inhibit TAK1 autophosphorylation and downstream NF-kappaB phosphorylation, suppress the production of inflammatory and catabolic factors such as MMP-3 and IL-6. TAK-756 exhibits anti-inflammatory effects in a rat joint inflammation model. TAK-756 can be used for the research of inflammatory joint disease, osteoarthritis[1].
Molecular Weight:
447.48
Formula:
C25H25N3O5
Target:
Leukotriene Receptor,MAP3K,MMP,NF-kappaB
Application Notes:
MCE Product type: Reference compound1
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