RO8994 (Compound 4) is an orally active, highly potent and selective spiroindolinone p53-MDM2 inhibitor with an IC50 value of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays). RO8994 induces up-regulation of p53 expression and Apoptosis in wild-type p53 cancer cells. RO8994 also inhibits tumor growth in the tumor xenograft model[1][2][3].
Molecular Weight:
613.51
Purity:
99.70
CAS Number:
[1309684-94-3]
Formula:
C31H31Cl2FN4O4
Target:
Apoptosis,E1/E2/E3 Enzyme,MDM-2/p53
Application Notes:
MCE Product type: Reference compound
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