LW1564 is an inhibitor for HIF-1alpha with an IC50 of 1.2 µM in HepG2. LW1564 inhibits mitochondrial respiration, reduces ATP production, stimulates HIF-1alpha degradation, and inhibits proliferation of various cancer cells with GI50 of 0.4-4.6 µM. LW1564 activates AMPK signaling pathway and inhibits lipid synthesis. LW1564 exhibits antitumor in HepG2 xenograft mouse model[1].
Molecular Weight:
731.84
CAS Number:
[2668337-39-9]
Formula:
C42H48F3N3O5
Target:
AMPK,HIF/HIF Prolyl-Hydroxylase
Application Notes:
MCE Product type: Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted
