Dofequidar (MS-209 free base) is an orally active quinoline compoundthat blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1). Dofequidar has highly potent reversing effect on multidrug-resistant tumor cells. Dofequidar competitively inhibits ABCB1/P-gp, ABCC1/MRP-1, blocks the efflux of chemotherapeutic agents, increases the drug concentration in cancer cells, and enhances the chemotherapeutic effect[1][2].
Molecular Weight:
481.59
Purity:
98.17
CAS Number:
[129716-58-1]
Formula:
C30H31N3O3
Target:
P-glycoprotein
Application Notes:
MCE Product type: Reference compound
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