Dofequidar fumarate (MS-209) is an orally active quinoline compoundthat blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1). Dofequidar fumarate has highly potent reversing effect on multidrug-resistant tumor cells. Dofequidar fumarate competitively inhibits ABCB1/P-gp, ABCC1/MRP-1, blocks the efflux of chemotherapeutic agents, increases the drug concentration in cancer cells, and enhances the chemotherapeutic effect[1][2].
Molecular Weight:
597.66
Purity:
98
CAS Number:
[153653-30-6]
Formula:
C34H35N3O7
Target:
P-glycoprotein
Application Notes:
MCE Product type: Reference compound1
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