BET-IN-28 (Compound 44) is a highly potent inhibitor of bromodomain and extra-terminal domain (BET), with an IC50 value of 4.47 nM against BRD4-BD1. BET-IN-28 blocks the interaction between BET proteins and N-acetylated lysine residues on histone tails, down-regulates certain genes. BET-IN-28 can be used for hematological malignancies and solid tumors study[1].
Molecular Weight:
499.57
Formula:
C26H29N9O2
Target:
Epigenetic Reader Domain
Application Notes:
MCE Product type: Reference compound
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