Autotaxin-IN-7 (45), a pyridine-2-carboxylic derivative, demonstrates subnanomolar ATX inhibition (IC50 = 0.086 nM), with a favorable heart safety profile (hERG > 30 µM) and minimal fibroblast toxicity. Autotaxin-IN-7 (45) suppresses the TGF-beta/Smad signaling pathway, downregulating alpha-smooth muscle actin (alpha-SMA) and extracellular matrix components (ECM). Autotaxin-IN-7 (45) is used in the research for pulmonary fibrosis[1].
Molecular Weight:
484.51
Formula:
C26H24N6O4
Target:
Phosphodiesterase (PDE),TGF-beta Receptor
Application Notes:
MCE Product type: Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted
