Gemcitabine triphosphate (dFdCTP) trisodium is the active metabolite of Gemcitabine (HY-17026). The mechanism of Gemcitabine triphosphate trisodium cell-killing is its competition with cytidine triphosphate during DNA replication, which results in the inhibition of chain elongation. Gemcitabine triphosphate trisodium shows a Ki of 11.2 µM against DNA polymerase alpha and 14.4 µM against DNA polymerase epsilon. Gemcitabine triphosphate trisodium partially inhibits dCMP deaminase and acts as a substrate for DNA synthesis to incorporate into cellular DNA and RNA. Gemcitabine triphosphate trisodium disrupts DNA and RNA synthesis, arrests cell cycle in G0/G1 and S phases, triggers apoptosis, reduces tumor cell proliferation. Gemcitabine triphosphate trisodium can be used for the research of pancreatic cancer and non-small cell lung cancer[1][2][3][4].
Molecular Weight:
569.08
Purity:
99.51
Formula:
C9H11F2N3Na3O13P3
Target:
Apoptosis,DNA/RNA Synthesis,Drug Metabolite
Application Notes:
MCE Product type: Reference compound
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