Ibetazol is a Importin beta1 (KPNB1) inhibitor and nucleocytoplasmic transport disruptor. Ibetazol binds covalently to Cys585 of Importin beta1, blocks both Importin beta1-mediated direct transport and Importin alpha-dependent nuclear import processes, without affecting transport mediated by other nucleocytoplasmic transport proteins. Ibetazol induces cytoplasmic accumulation of Importin alpha1, and inhibits nuclear import of substrates carrying nuclear localization signals (NLS), including the NLS-cMyc reporter gene, RelA/p65 and SREBP1. Ibetazol triggers spindle malformation and chromosome misalignment by disrupting the mitotic function of Importin beta1. Ibetazol inhibits the proliferation of cells expressing wild-type Importin beta1. Ibetazol has a high activity-cytotoxicity window, lacks intrinsic fluorescence, and acts rapidly on nucleocytoplasmic transport processes. Ibetazol serves as a tool compound for investigating nuclear import processes specifically mediated by Importin beta1[1].
Molecular Weight:
300.30
Purity:
99.80
Formula:
C13H11F3N2OS
Target:
Ras
Application Notes:
MCE Product type: Reference compound
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