NLRP3-IN-60 (Compound 39) is the orally active inhibitor for NLRP3. NLRP3-IN-60 inhibits pyroptosis with an IC50 of 13 nM in THP-1 cell. NLRP3-IN-60 inhibits IL-1beta release with an IC50 of 225 nM in human whole blood[1].
Molecular Weight:
490.52
Formula:
C23H24F2N4O4S
Target:
NOD-like Receptor (NLR),Pyroptosis
Application Notes:
MCE Product type: Reference compound
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