ER degrader 10, CAS [[3035311-43-1]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-170377
Supplier Catalog Number:
HY-170377
Alternative Catalog Number:
MCE-HY-170377-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
ER degrader 10 (Compound 51) is a selective, orally active degrader and antagonist for estrogen receptor (ER) with a DC50 of 0.43 nM and an IC50 of 0.56 nM. ER degrader 10 inhibits the proliferation of ER-positive cells with IC50s of 0-15 nM. ER degrader 10 exhibits a weak inhibitory activity against hERG channel with an IC50 >40 µM. ER degrader 10 is blood-brain barrier penetrable with a brain/plasma ratio (Kp) of 3.05. ER degrader 10 exhibits antitumor efficacy in mice model[1].
Molecular Weight:
497.60
CAS Number:
[3035311-43-1]
Formula:
C28H29F2NO3S
Target:
Estrogen Receptor/ERR,Potassium Channel
Application Notes:
MCE Product type: Reference compound1
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