HGC652 is the molecular glue, that targets E3 ubiquitin ligase TRIM21, promotes the formation of a ternary complex between TRIM21 and NUP98, induces degradation of NUP155 and nuclear pore complex proteins, thereby causing the cell death. HGC652 inhibits the proliferation of multi cancer cells, according to the expression level of TRIM21[1].
Molecular Weight:
449.60
Purity:
98.86
CAS Number:
[3055558-98-7]
Formula:
C23H28FNO3S2
Target:
E1/E2/E3 Enzyme,Molecular Glues
Application Notes:
MCE Product type: Reference compound
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