GSK-3beta inhibitor 23 (Compound 11726169) is the inhibitor for glycogen synthase kinase-3, that inhibits GSK-3beta and GSK-3alpha with IC50 of 12.1 nM and 18.8 nM. GSK-3beta inhibitor 23 exhibits antiviral activity against HIV 1. GSK-3beta inhibitor 23 exhibits good metabolic stablility in mouse/human liver microsomes and plasma, but poor Caco-2 permeability (which predicts low oral bioavailability)[1].
Molecular Weight:
434.30
Formula:
C18H13Cl2N5O2S
Target:
GSK-3
Application Notes:
MCE Product type: Reference compound
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