HDAC6 degrader-5 (Compound 6) exhibits inhibitory and degradation activity against HDAC6, with an IC50 of 4.95 nM and a DC50 of 0.96 nM. HDAC6 degrader-5 inhibits the release of TNF-alpha, IL-1beta and IL-6, blocks the hepatocyte apoptosis. HDAC6 degrader-5 exhibits anti-inflammatory activity in mouse APAP (HY-66005)-induced liver injury models[1].
Molecular Weight:
378.42
Purity:
99.55
Formula:
C21H22N4O3
Target:
Apoptosis,HDAC,Interleukin Related
Application Notes:
MCE Product type: Reference compound
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