CHD-1 is a a hypoxia-activated antitumor prodrug. CHD-1 impairs mitochondrial morphology and membrane potential in hypoxic tumor cells, further triggering excessive mitophagy and inducing apoptosis. CHD-1 inhibits the growth of hypoxic tumor cells in vitro and the growth of HeLa xenograft in vivo[1].
Molecular Weight:
301.27
CAS Number:
[3041166-70-2]
Formula:
C16H12FNO4
Target:
Apoptosis,Mitophagy
Application Notes:
MCE Product type: Reference compound
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