Tubulin polymerization-IN-73 (Compound 37) is an inhibitor for microtubule polymerization with an IC50 of 1.8 µM. Tubulin polymerization-IN-73 arrests the cell cycle at G2/M phase, induces apoptosis in A549 cell, inhibits the proliferation of A549 WT and A549/T resistant cell with IC50 of 0.023 µM and 0.057 µM. Tubulin polymerization-IN-73 exhibits antitumor efficacy in mouse model[1].
Molecular Weight:
405.45
Formula:
C23H23N3O4
Target:
Apoptosis,Microtubule/Tubulin
Application Notes:
MCE Product type: Reference compound
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