PARP1 PROTAC 180055 (Compound 180055) is a selective PARP1 PROTAC degrader (DC50 in T47D and MDA-MB-231 cell lines is 180 nM and 240 nM, respectively). PARP1 PROTAC 180055 promotes ubiquitination and degradation of PARP1 as well as inhibits PARP1 enzyme activity without a noticeable DNA trapping effect. PARP1 PROTAC 180055 inhibits tumors carrying BRCA mutations with a minor impact on the growth of normal cells (Pink: PARP1 ligand (HY-10617A), Blue: E3 ligase VHL ligand (HY-125845), Black: linker (HY-W014787))[1].
Molecular Weight:
920.14
Purity:
98.90
Formula:
C51H62FN7O6S
Target:
PARP,PROTACs
Application Notes:
MCE Product type: Reference compound
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