RdRP-IN-9 (Compound 6b) is a reversible covalent allosteric inhibitor of RdRp. RdRP-IN-9 demonstrates high anti-coronavirus activity, with an EC50 value of 0.68 µM against HCoV-OC43 RdRP-IN-9 exerts a more prolonged antiviral effect by reversibly acylating Cys12 in the NiRAN domain of non-structural protein 12 (nsp 12) and exhibits synergistic anti-coronavirus activity with Molnupiravir (HY-135853) [1].
Molecular Weight:
343.37
CAS Number:
[1101848-34-3]
Formula:
C19H21NO5
Target:
SARS-CoV
Application Notes:
MCE Product type: Reference compound
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