M3686 (Compound 29) is a potent, selective TEAD1 inhibitor with an IC50 value of 51 nM. M3686 also shows weaker binding activity on TEAD3. M3686 potently inhibits cell viability against YAP-dependent NCI-H226 cell line with an IC50 value of 0.06 uM. M3686 shows strong anti-tumor effects in the NCI-H226 xenograft model[1].
Molecular Weight:
429.40
CAS Number:
[2738550-24-6]
Formula:
C21H18F3N5O2
Target:
YAP
Application Notes:
MCE Product type: Reference compound
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