ATX-IN-1 (compound 35) is an inhibitor of ATX (IC50=0.7 nM) with anti-inflammatory activity. ATX-IN-1 can inhibit TGF-beta/Smad pathway and reduce collagen deposition to alleviate Bleomycin (HY-108345)-induced fibrosis in mice. ATX-IN-1 has good oral bioavailability (F=69.5%) and particle stability[1].
Molecular Weight:
486.48
Formula:
C25H22N6O5
Target:
Phosphodiesterase (PDE)
Application Notes:
MCE Product type: Reference compound
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