DSM1465 (Compound 82) is a potent, selective inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 value of 15 nM, inhibits P. falciparum 3D7 (Pf3D7) parasites with an EC50 value of 1.4 nM. DSM1465 shows potent in vivo activity in the humanized P. falciparum mouse model[1].
Molecular Weight:
467.75
Formula:
C17H12ClF6N5O2
Target:
Dihydroorotate Dehydrogenase,Parasite
Application Notes:
MCE Product type: Reference compound
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