CIB-L43 is an orally active TRBP inhibitor (KD = 4.78 nM) and enhances disruption of TRBP-Dicer interactions (IC50 = 2.34 µM). CIB-L43 suppresses oncogenic miR-21 biosynthesis, increasing PTEN and Smad7 expression and inhibiting AKT and TGF-beta signaling, thereby reducing HCC cell proliferation and migration[1].
Molecular Weight:
304.36
Purity:
99.71
CAS Number:
[1082942-70-8]
Formula:
C15H16N2O3S
Target:
Akt,PTEN,TGF-beta/Smad
Application Notes:
MCE Product type: Reference compound
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