Menin-KMT2A-IN-1 (Compound 20) is the inhibitor for menin-KMT2A that binds to menin with an IC50 of 8 nM, and inhibits the interaction between menin and lysine methyltransferase 2A (KMT2A). Menin-KMT2A-IN-1 inhibits hERG with an IC50 of 65 µM. Menin-KMT2A-IN-1 inhibits cell MV4-11 with an IC50 of 74 nM. Menin-KMT2A-IN-1 exhibits good pharmacokinetic characteristics in CD-1 mouse with an orally bioavailability of 74%[1].
Molecular Weight:
522.61
Formula:
C28H35FN6O3
Target:
Epigenetic Reader Domain,Potassium Channel
Application Notes:
MCE Product type: Reference compound
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