SHP2-IN-35 (Compound 3f) is the inhibitor for SHP2. SHP2-IN-35 exhibits antiproliferative activity in cancer cells RKO, SW480 and CT26 with IC50 of 5.72 µM, 3.71 µM and 1.42 µM, respectively. SHP2-IN-35 inhibits the PI3K-Akt signaling pathway, regulates the cell cycle associated gene expressions, and induces mitochondrial-related autophagy. SHP2-IN-35 inhibits the expression of certain cytokines and chemokines in the tumor microenvironment (TME), thereby regulating the tumor progression[1].
Molecular Weight:
592.46
Formula:
C34H32FeO6
Target:
Akt,Autophagy,PI3K,SHP2
Application Notes:
MCE Product type: Reference compound
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