BAG3/HSP70-IN-1 (compound 16) is the first-in-class BAG3 and HSP70 dual inhibitor. BAG3/HSP70-IN-1 binds to BAG3 full-length, BAG3-BD, and HSP70 proteins with Kds of 33.10 µM, 27.90 µM, and 33.80 µM, respectively. BAG3/HSP70-IN-1 inhibits HeLa cells with an IC50 of 49.46 µM. BAG3/HSP70-IN-1 induces apoptosis by activating caspase 3 and caspase 9 levels in HeLa cells. BAG3/HSP70-IN-1 elevates p21 levels while reduces FOXM1 expression in HeLa cells. BAG3/HSP70-IN-1 decreases ATPase activity[1].
Molecular Weight:
537.65
Formula:
C28H39N7O4
Target:
Apoptosis,Caspase,HSP
Application Notes:
MCE Product type: Reference compound
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