EGFR-IN-150, CAS [[3037323-16-0]] Preis auf Anfrage

Product Overview

• Article Name: EGFR-IN-150, CAS [[3037323-16-0]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-170968
• Supplier Catalog Number: HY-170968
• Alternative Catalog Number: MCE-HY-170968-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

EGFR-IN-150 is an EGFR inhibitor that effectively suppresses the phosphorylation of mutant epidermal growth factor receptor (EGFR) and its downstream AKT signaling pathway, thereby exerting antitumor effects and inducing HMOX1 expression to trigger ferroptosis. EGFR-IN-150 exhibits an IC50 of 0.386 µM against the non-small cell lung cancer (NSCLC) cell line H1975, and significantly inhibits colony formation and migration of both H1975 and A549 cells while inducing apoptosis. In addition, EGFR-IN-150 markedly suppresses tumor growth in the H1975 cell-derived xenograft (CDX) mouse model. EGFR-IN-150 holds promise for research related to non-small cell lung cancer[1].

Product Properties

• Molecular Weight: 522.98
• CAS Number: [3037323-16-0]
• Formula: C29H23ClN6O2
• Target: Apoptosis,EGFR

Application Notes

• Application Notes: MCE Product type: Reference compound