MS910 is an efficient and selective MEK1/2 PROTAC degrader. MS910 exhibits effective MEK1/2 degradation ability and anti proliferative activity in various cancer cells, such as HT-29 (MEK1 DC50 = 118 nM, MEK2 DC50 = 55 nM) and SK-MEL-28 (MEK1 DC50 = 94 nM, MEK2 DC50 = 38 nM) cells. MS910 is commonly used in cancer research. (Pink: MEK1/2 Ligand (HY-10254), Blue: CRBN Ligand (HY-W087383), Black: Linker (HY-W022240))[1]
Molecular Weight:
984.75
CAS Number:
[2756323-28-9]
Formula:
C41H48F3IN6O11
Target:
MEK,PROTACs
Application Notes:
MCE Product type: Reference compound1
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