MC-25B is a specific FKBP12 PROTAC degrader. MC-25B degrades FKBP12 with a DC50 of 0.35 µM and a Dmax of 89%. MC-25B facilitates the degradation of nuclear-localized FKBP12 through a DCAF16-dependent mechanism. (Pink: FKBP12 ligand (HY-170988), Blue: E3 ligase ligand HY-170986), Black: linker (HY-128844), FKBP12 ligand+ linker (HY-170987))[1].
Molecular Weight:
1230.92
Formula:
C65H92ClN7O14
Target:
FKBP
Application Notes:
MCE Product type: Reference compound1
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