Autophagy agonist-1 (compound 22) is an Autophagy agonist. Autophagy agonist-1 exhibits significant anticancer activity against HepG2 cells and normal cells with IC50s of 8.8 µM and > 50 µM. Autophagy agonist-1 induces G1/S phase cell cycle arrest and inhibits CDK4 and CyclinD1 expression while upregulating P21. Autophagy agonist-1 promotes the accumulation of autophagosomes and the proteins LC3 and PINK1, enhancing autophagy and mitophagy in HepG2 cells[1].
Molecular Weight:
559.70
Formula:
C33H41N3O5
Target:
Atg8/LC3,Autophagy,CDK,PINK1/Parkin
Application Notes:
MCE Product type: Reference compound
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