Pro-GA is a gamma-glutamyl cyclotransferase (GGCT) inhibitor. Pro-GA inhibits the enzymatic activity of GGCT, disrupts glutathione homeostasis, induces the production of mitochondrial ROS, and upregulates the expression of p21, p27 and p16 in cells. Pro-GA inhibits the growth of cancer cells, induces cell cycle arrest and cellular senescence. Pro-GA exerts anti-tumor effects in breast cancer xenograft mouse models. Pro-GA can be used in research related to bladder cancer and breast cancer[1][2].
Molecular Weight:
289.28
Purity:
97.86
CAS Number:
[2222067-12-9]
Formula:
C12H19NO7
Target:
Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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