P1D-34 is a Pin1 PROTAC degrader with a DC50 value of 177 nM. P1D-34 also down-regulates Pin1 client proteins such as Cyclin D1, Rb, Mcl-1, Akt, and c-Myc. P1D-34 shows anti-proliferative activities in a panel of acute myeloid leukemia (AML) cell lines. P1D-34 induces cell DNA damage and apoptosis by releasing ROS generation. Pink: PIN1 ligand (HY-171442A), Blue: CRBN ligand (HY-14658), Black: Linker (HY-W014883)[1].
Molecular Weight:
835.45
Formula:
C40H59ClN6O9S
Target:
Akt,Apoptosis,CDK,c-Myc,PIN1,PROTACs,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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