SIK2-IN-3 is an orally active SIK1/2 selective inhibitor (IC50: 0.128/0.084 µM). SIK2-IN-3 inhibits CRTC3 phosphorylation and myeloid cell pro-inflammatory cytokine production. SIK2-IN-3 ameliorates systemic and tissue inflammatory responses in a mouse anti-CD40 colitis model[1].
Molecular Weight:
416.48
CAS Number:
[2810809-10-8]
Formula:
C23H24N6O2
Target:
Salt-inducible Kinase (SIK)
Application Notes:
Reference compound
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