dAurAB2 is a dual-degrading PROTAC that potently degrades Aurora-A and Aurora-B with DC50s of 59 nM and 39 nM, respectively. dAurAB2 reduces N-Myc levels in MYCN-amplified IMR32 neuroblastoma cells. dAurAB2 can be used for the study of neuroblastoma. (Pink, Aurora ligand (HY-10804), Blue, E3 ligand: (HY-103597), Black, linker (HY-W105740))[1].
Molecular Weight:
1049.02
Purity:
98.61
Formula:
C52H62BrN11O8
Target:
Aurora Kinase,PROTACs
Application Notes:
MCE Product type: Reference compound
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