OPB-3206 is a selective matrix metalloproteinase (MMP) inhibitor. OPB-3206 inhibits interstitial collagenase, gelatinase A (MMP-2), gelatinase B (MMP-9) and stromelysin with IC50 values of 7*10-7 M, 5*10-6 M, 5*10-7 M and 2*10-6 M, respectively. OPB-3206 reversibly binds to the zinc-binding region of MMPs, preventing the activation of MMP-9 and reducing extracellular matrix degradation to inhibit tumor lung metastasis. OPB-3206 is promising for research of lung metastasis of osteosarcoma[1].
Molecular Weight:
363.41
CAS Number:
[166245-54-1]
Formula:
C18H25N3O5
Target:
MMP
Application Notes:
MCE Product type: Reference compound
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