MS105 (YX39-105) is an orally active and selective protein tyrosine kinase 6 (PTK6) (BRK) PROTAC degrader. MS105 recruits VHL E3 ligase via a VHL ligand moiety, promotes PTK6 ubiquitination and proteasomal degradation, inhibits the proliferation and migration of breast cancer cells, and induces apoptosis. MS105 shows potential for use in breast cancer research[1].
Molecular Weight:
1072.30
Purity:
98.27
CAS Number:
[2408339-39-7]
Formula:
C56H70FN13O6S
Target:
Apoptosis,PROTACs,Tyrosinase
Application Notes:
MCE Product type: Reference compound1
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