FC-14367 is a PROTAC degrader targeting HIV-1 Nef protein. FC-14367 forms a ternary complex by binding Nef and Cereblon E3 ubiquitin ligase, inducing Nef ubiquitination and proteasomal degradation, restoring cell-surface CD4 and MHC-I expression and inhibiting HIV-1 replication. FC-14367 can be used in research on HIV infection and AIDS[1]. (Black: Glycolic acid (HY-W015967), Blue: 2-(2,6-Dioxopiperidin-3-yl)phthalimidine (HY-138793))
Molecular Weight:
740.18
CAS Number:
[3066893-65-7]
Formula:
C38H35ClFN7O6
Target:
HIV,PROTACs
Application Notes:
MCE Product type: Reference compound
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