Lipid 114 is an ionizable cationic lipid with a pKa of approximately 6.8. Lipid 114 can be used to generate lipid nanoparticles (LNP) to deliver siRNA in vitro as well as in vivo. Lipid 114 LNPs encapsulating siRNA that targets IL-1beta can reduce IL-1beta expression in macrophages. Lipid 114 LNPs encapsulating siRNA that targets IL-1beta also reduces hepatic and renal expression of IL-1beta, as well as decreasing hepatic inflammation in mouse model with LPS-induced acute liver failure[1].
Molecular Weight:
1544.51
Formula:
C95H186N4O10
Target:
Liposome
Application Notes:
MCE Product type: Oligonucleotides
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