Tubulin/MMP-IN-3 (Compound 15j) is the dual inhibitor for tubulin polymerization and MMP, and inhibits MMP-2 and MMP-9 with IC50 of 21.13 µM and 19.24 µM. Tubulin/MMP-IN-3 inhibits NF-kappaB signaling pathway, causes mitochondrial dysfunction and the apoptosis through a mitochondrial-dependent pathway. Tubulin/MMP-IN-3 exhibits antiproliferative activity in a variety of cancer cells, arrests the cell cycle at G2/M phase, and exhibits antitumor efficacy in mouse models[1].
Molecular Weight:
748.71
Formula:
C38H41N2O12P
Target:
Apoptosis,Microtubule/Tubulin,MMP,NF-kappaB
Application Notes:
MCE Product type: Reference compound
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