BG11 induces the accumulation of Fe2+ and intracellular lipid peroxides, induces ferroptosis. BG11 regulates the expression of Bax and Bcl-2 proteins, and induces apoptosis in MDA-MB-231 cell. BG11 arrests the cell cycle at G0/G1 and S phase, inhibits the proliferation of TNBC cancer cell (IC50 for MDA-MB-231 and BT549 is 0.49 µM and 0.52 µM), and inhibits the cell migration and invasion. BG11 exhibits antitumor efficacy in mouse models[1].
Molecular Weight:
559.51
CAS Number:
[3065877-52-0]
Formula:
C26H28Cl2N6O2S
Target:
Apoptosis,Ferroptosis
Application Notes:
MCE Product type: Reference compound
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